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WideScreen® BeadPlex™ Luminex-Based Multiplex Assays

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Cancer Biomarkers

DescriptionSpeciesNo. of AnalytesTarget Proteins
WideScreen Human Cancer Panel 1 (Tumor Markers) Human 6 CA 125, CA 19-9, CEA, AFP, Prolactin, CA 15-3
WideScreen Human Cancer Panel 2 (Growth Factors) Human 12 VEGF, PlGF, Epiregulin, PDGF, HB-EGF, Tenascin C, EGFR, TGF-α, Amphiregulin, BTC, FGF-basic, EGF
WideScreen Human Breast Cancer Panel 1 Human 6 Angiopoietin-2, PAI-1, Progesterone Receptor, IGF-1R, HER-2 (erbB2), Angiogenin
WideScreen Human Breast Cancer Panel 2 Human 5 EGFR, Estrogen Receptor α, Fas, TIMP-2, VEGFR2
WideScreen Human Breast Cancer Panel 3 Human 4 TIMP-1, E-cadherin, uPA, IGFBP-3
BeadPlex® Phospho-EGFR Profiling Panel 9-Plex New Human 9 Total EGFR and 8 site specific phosphorylation sites (Thr654, Thr669, Tyr845, Tyr1045, Ser1047, Tyr1068, Tyr1086, and Tyr1173)

Cardiovascular Disease

DescriptionSpeciesNo. of AnalytesTarget Proteins
WideScreen Human CVD Panel 1 (Apolipoproteins)  Human 7 ApoAI, ApoE, ApoAII, ApoH, ApoB, ApoJ, ApoCIII
WideScreen Human CVD Panel 2 (Inflammation)  Human 6 IL-6, MIP-1α, IL-8, MIP-1β, MCP-1, TNF-α
WideScreen Human CVD Panel 3  Human 6 E-selectin, P-selectin, ICAM-1, Leptin, Osteopantin, sRAGE
WideScreen Human CVD Panel 4  Human 6 H-FABP, MPO, LOX-1, NT-Pro-BNP, MDA-LDL, Thrombomodulin
WideScreen Human CVD Panel 5 (Acute Phase)  Human 8 α2-M (α2-macroglobulin), SAP (serum amyloid P), CRP (C-reactive protein), vWF (von Willebrand factor), Fetuin A, Lp(a) (lipoprotein(a)), Fibrinogen, Haptoglobin
WideScreen Human CVD Panel 6  Human 5 Adiponectin, EN-RAGE, PAI-1, Cystatin C, VCAM-1
BeadPlex® Mouse CVD Panel 1 New  Mouse   Clusterin, C-Reactive Protein (CRP), Cystatin C, Haptoglobin, and Serum Amyloid P (SAP)

Toxicity

DescriptionSpeciesNo. of AnalytesTarget Proteins
BeadPlex® Human Kidney Toxicity/Injury Panel 1 New  Human 8 Calbindin, Clusterin/ApoJ, GSTα, GSTπ, KIM-1, SCF, TIMP-1, & VEGF-A
BeadPlex® Human Kidney Toxicity/Injury Panel 2 New  Human 4 β-2 Microglobulin, Cystatin C, NGAL, & Osteopontin
BeadPlex® Human Kidney Toxicity/Injury Panel 3 New  Human 3 Albumin, TFF3, THP
Human Mitochondrial Toxicity: Oxidative Phosphorylation (OXPHOS) Panel New  Human 6 Complex I (NADH–Ubiquinone Oxidoreductase), Complex II (Succinate Ubiquinone Oxidoreductase), Complex III (Ubiquinone Cytochrome C Oxidoreductase), Complex IV (Cytochrome C Oxidase), Complex V (ATP Synthase), and NNT (Nicotinamide Nucleotide Transhydrogenase)

Hormone

DescriptionSpeciesNo. of AnalytesTarget Proteins
WideScreen Human Hormone Panel 1  Human 5 Follicle stimulating hormone (FSH), Progesterone, hCG-B, Testosterone, Luteinizing hormone

Matrix Metalloproteinase

DescriptionSpeciesNo. of AnalytesTarget Proteins
WideScreen Human MMP Panel  Human 6 MMP-1, MMP-9, MMP-3, MMP-10, MMP-8, MMP-13

Nephrotoxicity

DescriptionSpeciesNo. of AnalytesTarget Proteins
WideScreen Rat Kidney Toxicity Panel 1  Rat 5 β2 Microglobulin, TIMP-1, GST-α, VEGF, KIM-1
WideScreen Rat Kidney Toxicity Panel 2  Rat 5 Calbindin, NGAL (Lipocalin), Clusterin, Osteopontin, Cystatin C

Cell Signaling

DescriptionSpeciesNo. of AnalytesTarget Proteins
WideScreen EpiTag™ ERK Pathway Panel 1   4 B-Raf (pS446, pS446), MEK1/2 (pS217, pS221/pS222, pS226), ERK1 Total (pT202/pY204), ERK2 Total (pT185/pY187)
WideScreen EpiTag™ ERK Pathway Panel 2   6 Raf-1 (Total), phospho-Raf-1 (Ser338), MEK1 (Total), MEK2 (Total), phospho-MEK1/2 (Ser217, Ser221/ Ser222, Ser226), STAT1 (Total)
WideScreen EpiTag™ ERK Pathway Additional Singleplex Analytes   14 Total and phospho-specific BeadKits™ for β-Raf (Ser446), Raf-1 (Ser338), MEK1 (Ser217/Ser221), MEK2 (Serr222/Ser226), Erk1 (Thr202/Tyr204), Erk2 (Thr185/Tyr187), RSK2 (Ser386), and STAT1 (Ser727)
WideScreen RTK Total Assays   7 EGFR (Total), IGF-1R (Total), Met (HGFR) (Total), PDGFRβ (Total), erbB2 (HER-2) (Total), VEGFR2 (FLK, KDR) (Total), Tie-2 (Total)
WideScreen RTK pTyr Assays   7 phospho-EGFR (Tyr), phospho-IGF-1R (Tyr), phospho-Met (HGFR) (Tyr), phospho-erbB2 (HER2) (Tyr), phospho-VEGFR2 (FLK,KDR) (Tyr), phospho-Tie2 (Tyr)

© Merck KGaA, Darmstadt, Germany, 2012


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